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Popular Articles

Screening Of First-Degree Relatives Of Patients With Bicuspid Aortic Valve Recommended
Bicuspid Aortic Valve (BAV), a condition in which patients" aortic valves have just two leaflets instead of the normal three, is the most common cardiac anomaly, affecting up to two percent of the general population. The defect can result in calcification deposits on the heart valve, leakage of the valve and may results in a feeling of tightness in the chest as well as shortness of breath. The condition is easily diagnosed; often physicians can hear a "click" or a murmur when they listen to a BAV patient"s heart with a stethoscope.

Designer Of The World's First Hand-Held, Non-Contact Vein Illumination Device Meets Stringent ISO 13485 Safety, Design And Distribution Standards
AccuVein LLC, maker of the AV300, the world"s first hand-held, non-contact vein illumination device, announced that its quality system has received an International Organization for Standardization (ISO) 13485 Certification. This certifies to customers around the globe AccuVein"s commitment to the quality and safety of its medical device design, development, production, installation and delivery procedures.
News of the day
THT's One-hour 'Fastest' Service Aims To Reduce Undiagnosed HIV In Brighton & Hove
In a bid to reduce levels of undiagnosed HIV in Brighton & Hove, HIV and sexual health charity Terrence Higgins Trust (THT) is encouraging gay and bisexual men who may have been at risk to attend a local service offering one-hour HIV testing. One in four people who have HIV in the UK are undiagnosed, and there are now more people living with the condition than ever before.
Oncology

A Breakthrough In Gastric Carcinogenesis

Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the hallmarks of human cancer. A research team led by Dr Eiji Oki from Kyushu University examined the methylation status of the promoter region of CHFR and microsatellite instability (MIN) status in primary gastric cancers. Their study was published on May 28, 2009 in the World Journal of Gastroenterology. They investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specific PCR. Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing. They found that twenty cases (33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors. The promoter methylation of CHFR was frequently accompanied with MIN. Seven of 20 (35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39 (7.7%) cases showed MIN in the non-methylated CHFR tumor (P World J Gastroenterol 2009; 15(20): 2520-2525. Correspondence to: Eiji Oki, MD, PhD, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Lai-Fu Li World Journal of Gastroenterology


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