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More Vigilant Monitoring For Seizures Among ICU Patients Encouraged
Two new studies published by neurologists at Columbia University Medical Center and NewYork-Presbyterian Hospital demonstrate a need for more vigilant monitoring for seizure activity among intensive care patients who may be experiencing subtle seizures that are typically unrecognized. These subtle seizures may be affecting patients" prognoses and causing long-term brain damage, death and severe disability.

Prepared Patient: Managing Mental And Medical Illness
In her 1984 boot camp graduation photo, Adrienne Fitts is smiling. Her hair is neatly groomed, her Navy cap and dress whites are spotless and she is regulation fit and trim.
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Plumper Heart Disease Patients Do Better, Live Longer
Being overweight or obese is a leading contributor to cardiovascular disease (CVD) and associated risk factors; however, in patients with established CVD, obesity appears to play a protective role. In fact, data suggest obese patients with heart disease do better and tend to live longer than leaner patients with the same severity of disease, according to a review article published in the May 26, 2009, issue of the Journal of the American College of Cardiology.
Medical Devices

A Link Between The Circadian Rhythm And Salt Balance

New research, conducted by Charles Wingo and his colleagues, at the University of Florida, Gainsville, suggests a link between the circadian rhythm and control of sodium (salt) levels in mice. The hormone aldosterone regulates levels of sodium in the blood and thereby helps control blood pressure. Although it is known that aldosterone regulates sodium levels by controlling expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC) in the kidney, the molecular pathway by which aldosterone modulates alpha-ENaC levels has not been determined. In a previous study to address this issue, Wingo and colleagues found that aldosterone induced expression of the circadian clock gene Per1 in mouse cells, but the effects of this induction were not investigated. In this new study, they have revealed that the protein produced from the Per1 gene (Period 1) regulates expression of alpha-ENaC in the mouse kidney. Importantly, in the absence of Period 1, expression of alpha-ENaC in the mouse kidney was decreased and sodium loss in the urine was increased. Since expression from the Per1 gene seemed to follow a circadian pattern, the authors suggest that the circadian clock has a role in balancing sodium levels in the body. TITLE: The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice Karen Honey Journal of Clinical Investigation


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