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Low And High Levels Of Hormone In Men With Heart Failure Associated With Increased Risk Of Death
Men with systolic chronic heart failure who have low or high levels of estradiol, a form of the hormone estrogen, have an increased risk of death compared with men with moderate levels of this hormone, according to a study in the May 13 issue of JAMA.

(Pet) Food For Thought Getting To The Bottom Of The Business
The world of pet food can be a dizzying place. Who makes what? Is the industry regulated? What information is - and isn"t - included on pet food labels? Have things changed at all since the massive pet food recall in 2007?
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FDA Approves Multaq(R) For Patients With Atrial Fibrillation Or Atrial Flutter
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) announced that the U.S. Food and Drug Administration (FDA) has approved Multaq(R) (dronedarone) 400 mg Tablets. Patients with atrial fibrillation (AF) or atrial flutter (AFL) soon will have a new treatment option to help improve current management of their disease. Multaq(R) is the first drug approved in the United States that has shown a clinical benefit to reduce cardiovascular hospitalization in patients with AF/AFL.
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A Novel Communication Role For CYP17A1 In The Progression Of Castration-Resistant Prostate Cancer

UroToday.com - This publication describes our unique finding that the steroidogenic enzyme CYP17A1 is present in prostate derived exosomes, isolated from human serum. We also describe CYP17A1 expression in human prostate tissues during castration resistant progression of cancer and identify a subcellular pattern of distribution for CYP17A1 consistent with a secretory protein in human prostate tissues, similar to that of PSA. Amongst the numerous proteins shown to be present in prostasomes we have found this key steroidogenic enzyme involved in testosterone synthesis from cholesterol. CYP17A1 is currently a target of investigational agents such as Abiraterone, which is under investigation for the treatment of advanced castration resistant disease. We postulate that this phenomenon is a cellular response triggered by upregulation of processes required for the cell to undergo cholesterol mediated steroid synthesis to testosterone and DHT within prostate tumour cells and is an adaptive resistance mechanism to depletion of androgens. Despite our inability to demonstrate metabolic enzyme activity in exosome isolates, we believe that CYP17A1 presence in the serum and its elevation in cancer patients compared with healthy controls suggests that it may be a novel diagnostic biomarker. Beyond its potential as a biomarker we propose that CYP17A1 could be playing a communication role in castrate resistant cancer development. In the absence of a supply of testicular androgens, when mechanisms involved in de novo androgen synthesis have been shown to be activated1, exosomal "life-rafts" are released from the cell, loaded with "adaptive survival messages" for other cells to host and potentially assimilate in order to enhance chances of survival. This hypothesis works on the basis that elevated cholesterol levels are observed in cancer cells during castration resistant development, which in turn has been shown to regulate an increase in the extrusion of prostate derived exosomes into the cancer microenvironment2, triggers the release of these "exosomal "life rafts". References: 1. Locke J, Guns ES, Lubik A, Adomat H, Hendy S, Wood C, Gleave ME, Nelson CC: De Novo Synthesis of Androgens as a Potential Mechanism behind Androgen-Independent Prostate Cancer Progression. Cancer Res. 2008 Aug 1;68(15):6407-15 2. Llorente A, van Deurs, B and Sandvig, K: Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. European Journal of Cell Biology 86 (2007) 405-415 Manuscript: Locke J, Fazli L, Adomat H, Smyl J, Weins K, Barr S, Lubik A, Hales B, Nelson CC, Gleave M and Tomlinson Guns ES: CYP17A1 is elevated in the serum of prostate cancer patients as compared to healthy controls. Prostate Mar 2009 [EPub ahead of print] Written by Emma Tomlinson Guns, PhD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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