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Characterization Of ERG, AR And PTEN Gene Status In Circulating Tumor Cells From Patients With Castration-Resistant Prostate Cancer
UroToday.com - The TMPRSS2-ERG gene fusion occurs in 30-70% of androgen deprivation therapy (ADT) naç¯ve prostate cancers (CaP), but its relevance in castration-resistant prostate cancer (CRPC) is less well defined. The TMPRSS2-ERG gene fusion is androgen driven. In the April 1, 2009 issue of Cancer Research, a group led by Dr. Johann de Bono evaluated patients undergoing treatment with the CYP17 inhibitor abiraterone acetate, which ablates the synthesis of androgens and estrogens that drive the TMPRSS2-ERG gene fusions. They hypothesized that androgen-dependent overexpression of ERG persisted in CRPC and that TMPRSS2-ERG tumors represented a subgroup of CaP that remained sensitive to abiraterone acetate. They hypothesized that two mechanisms of resistance to abiraterone acetate were gain of AR and loss of PTEN that could result in constitutive phosphorylation of AR, leading to ligand-independent activation.

Regulator Says NHS Must Do More To Protect Children From Neglect And Abuse
CQC publishes national review of NHS child safeguarding
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California Lawmaker Introduces Legislation To Support National Caribbean American HIV/AIDS Awareness Day
Rep. Barbara Lee (D-Calif.) introduced legislation that seeks to encourage state and local governments, as well as media organizations, to recognize June 8th as National Caribbean American HIV/AIDS Awareness Day, the American Chronicle reports. The legislation also supports the development of a national AIDS strategy that aims to reduce new HIV infections in the U.S., particularly among minorities (American Chronicle 6/9).
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California Lawmaker Introduces Legislation To Support National Caribbean American HIV/AIDS Awareness Day

Rep. Barbara Lee (D-Calif.) introduced legislation that seeks to encourage state and local governments, as well as media organizations, to recognize June 8th as National Caribbean American HIV/AIDS Awareness Day, the American Chronicle reports. The legislation also supports the development of a national AIDS strategy that aims to reduce new HIV infections in the U.S., particularly among minorities (American Chronicle 6/9). This information was reprinted from dailyreports.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily U.S. HIV/AIDS Report, search the archives and sign up for email delivery at dailyreports.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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