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Visit To The Doctor: The Supply Of Additional Private Services Is Increasing
Panel physicians are increasingly offering individual health services (IHS) to patients with statutory health insurance. This is documented by Susanne Richter et al. of the Department of Social Medicine, Lubeck University, in the new edition of Deutsches Arzteblatt (Dtsch Arztebl Int 2009; 106(26): 433-9). IHS include medical health services which are not reimbursed by the health insurance funds and which the patient has to pay for himself.

Early Switch From Cyclosporine To Sirolimus After Renal Transplantation Produces Sustained Improvement In Renal Function
BOSTON - Favorable 12-month outcomes are maintained through 30 months of follow-up when renal transplant patients are converted from a cyclosporine (CsA)-based regimen to a sirolimus (SRL)-based regimen three months post-transplant, according to results of the CONCEPT study announced here at the American Transplant Congress (ATC) 2009.
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Unjust Stigma, Lack Of Physician Training Hinder Market For IUDs, Opinion Piece Says
Intrauterine devices "seem like the perfect form of contraception: simple to use, long-lasting, reversible, hormone-free, economical," Slate columnist Kate Klonick writes. She asks, "So why are American women so late to this party? Perhaps the better question is: Why did they leave the party to begin with?"Klonick explains the benefits of IUDs, calling them a "foolproof method of birth control" and noting that they are 99% effective and "can last up to 10 years." Although IUDs can cost between $300 and $500, it is a one-time expense that is often covered by insurance, according to Klonick. She notes that although efficacy studies show that birth control pills, patches and vaginal rings can be "99% effective in a clinical setting, real-life compliancy -- like forgetting to take the pill at the same time every day -- reduces its success rate." Klonick adds that the availability of hormone-free IUDs makes them an "ideal" option for "women prone to some of the negative effects of hormonal birth control, like weight gain, mood swings, acne or high blood pressure."According to Klonick, IUDs were used by almost 10% of U.S. women taking birth control in the late 1970s but are now used by less than 2% of such women. She writes that Katharine O"Connell, a gynecologist at Columbia University who specializes in contraception, believes IUDs still carry a stigma "due to the erroneous belief that they"re highly dangerous" partly due to a number of deaths that occurred in the early 1970s tied to a specific brand of IUD known as the Dalkon Shield. Because of bad publicity surrounding the devices, "the U.S. pharmaceutical industry abandoned the research and manufacturing of IUDs in the mid-1980s, claiming the devices were no longer profitable," Klonick states. According to O"Connell, most experts now agree that the Dalkon Shield"s problems were related to its design, which made users more susceptible to infection, and a lack of testing for sexually transmitted infections before insertion.There are now two major brands of IUDs -- Mirena and ParaGard -- on the U.S. market, but physican training remains a problem, according to Klonick. She writes that studies show that premedical students are not educated regarding IUDs to the extent they are about oral contraceptive pills. O"Connell also noted that many medical schools limit classes on contraception to one lecture, which often omits IUDs. Klonick writes, "This lack of training can leave many doctors feeling uncomfortable recommending the once-controversial devices to their patients." She adds that many physicians who know how to insert and remove IUDs "still refuse to recommend it to childless patients because of the device"s checkered history." She concludes, "With Mirena advertising on television, the downturn in the economy forcing people to economize, and more women concerned about the long-term effects hormones have on their bodies, perhaps the IUD"s stigma will finally become a thing of the past" (Klonick, Slate, 7/29).
Nutrition

Cempra Pharmaceuticals Closes $46 Million Series C Financing

Cempra Pharmaceuticals, Inc., a clinical-stage company developing novel antibiotics for difficult-to-treat and drug-resistant infections, announced that it has successfully raised $46 million in a Series C financing. The funds will be used for the continued clinical development of CEM-101, Cempra"s lead macrolide compound; CEM-102, its promising oral antibiotic for gram-positive infections; and other preclinical stage, non-antibacterial macrolide programs. Quaker BioVentures led the Series C round, which also included Devon Park Bioventures, as well as original investors, Aisling Capital, Intersouth Partners, investment banker Wistar Morris III, and Teachers" Private Capital. Geeta Vemuri, Ph.D., Partner at Quaker BioVentures, will join the board with this financing. "Antibiotic resistance is an increasingly daunting major public health challenge, and Quaker is committed to supporting companies that are advancing the most promising solutions," said Dr. Vemuri. "With two compounds in active clinical development, Cempra addresses a critical, growing need for novel and potent antibiotics. We are excited to help the company continue to rapidly build a leading position in this field." "Our investment in Cempra is Quaker"s seventh investment in North Carolina, which we believe is a quickly growing center of innovation for the life science industry," said Sherrill Neff, Partner, Quaker BioVentures. Cempra is nearing completion of a Phase I trial for its lead antibiotic candidate, CEM-101, for which the company is developing both intravenous and oral formulations to allow treatment of moderate and severe community-acquired bacterial pneumonia. The company expects to begin Phase II studies later this year. CEM-101, which Cempra believes is the most potent macrolide in development, shows activity against macrolide-resistant organisms and the potential to treat a broad range of clinically significant, difficult-to-treat infections such as pneumococcal and mycoplasma pneumonia. Cempra also anticipates it will begin pivotal clinical trials in the second half of 2009 for CEM-102, an oral antibiotic that is active against gram-positive bacteria and is expected to be used to treat patients with complicated skin and skin structure infections caused by community-acquired and hospital-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA and HA-MRSA). "This additional funding represents strong confidence in our approach to address the need for new antibiotics, particularly those that will be used to treat drug-resistant infections, and it will help us advance our clinical development of these very promising compounds," commented Prabhavathi Fernandes, Ph.D., President and Chief Executive Officer of Cempra. "The Infectious Disease Society of America has cited that the top three needs in antibacterials are treatments for multi-drug resistant pneumococcus, MRSA, and gram negative pathogens. With CEM-101 potentially indicated for community-acquired bacterial pneumonia, and CEM-102 being developed for complicated skin infections, including MRSA, we are making great strides to address two of those three needs." The Chairman of Cempra"s Board of Directors, Garheng Kong, M.D., Ph.D., General Partner at Intersouth Partners, added, "It"s encouraging to see that even in the current economic environment, a company like Cempra, with an innovative approach and promising compounds, can attract strong investors that enable it to deliver on its mission to serve the global patient population." About Quaker BioVentures Quaker BioVentures is a venture capital firm with $700 million under management, dedicated to investing in life science companies in the Mid-Atlantic region and contiguous states. The firm leads investments in companies across the spectrum of the life science industry, including biopharmaceuticals, medical devices, human diagnostics, specialty pharmaceuticals, and healthcare services. Quaker BioVentures invests in companies at all stages of development, from early stage businesses to public companies. Please visit Quaker BioVentures" website at http://www.quakerbio.com. About Devon Park Bioventures Devon Park Bioventures, founded in 2006, is a healthcare venture capital firm with a primary focus on therapeutics companies. Based in the Philadelphia area, the firm seeks to invest in companies which have significant commercial potential based on propriety products, attractive clinical development plans and superior management teams. The General Partners of Devon Park have a longstanding history in the biotechnology business, having been lead or co-lead investor in over 25 biotechnology companies over the past 18 years. For additional information, please visit http://www.dpbioventures.com Cempra Pharmaceuticals, Inc.


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