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Undiagnosed Celiac Disease Associated With Nearly Quadrupled Mortality
Celiac disease, an immune system reaction to gluten in the diet, is over four times more common today than it was 50 years ago, according to findings of a Mayo Clinic study published this month in the journal Gastroenterology.

Obama's Embryonic Stem Cell Proposal Goes 'Only Halfway' To Improving Research, Columnist Says
The Obama administration"s draft guidelines outlining criteria for federal funding of stem cell research "go only halfway toward freeing embryonic stem cell research" because "[s]ome of the most promising investigations will still be denied federal funding," syndicated columnist Froma Harrop writes in a Providence Journal opinion piece. Harrop writes that although "the public supports the research by more than two to one," there is "a vocal minority opposed to this work because it requires the destruction of embryos." According to Harrop, although Obama allowed research on embryos willingly donated by fertility clinic patients and lifted former President George W. Bush"s restrictions limiting federal funding to research on 21 existing stem cell lines, he "wouldn"t budge on the prohibition against funding research that allows for the creation of embryos out of human cells," known as therapeutic cloning. She notes that "therapeutic cloning has little to do with human cloning, which is about making new people and is illegal most everywhere. But say that cloning is being used in research, and many folks think they"re going to have a clone as a neighbor in a few years."Harrop continues, "[B]y allowing the use of embryos from fertility clinics and not those created by researchers, the administration lends credence to the view that embryos are full human beings." However, the "only difference between embryos in fertility clinics and the ones cloned for research is the motive of the people who created them." She concludes, "Obama"s timidity in rewriting the guidelines has slowed down important research and produced more confusion. And for Americans praying for cures from this science, the choice seems rather clear" (Harrop, Providence Journal, 5/28).
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Drug Combination Improves Outcome For Advanced Non-Small Cell Lung Cancer
A new, international study found that the combination of two drugs delays disease progression for patients with advanced non-small cell lung cancer (NSCLC). Results from the Phase III "ATLAS" trial were presented today by Dr. Vincent Miller of Memorial Sloan-Kettering Cancer Center (MSKCC) at the American Society of Clinical Oncology Annual Meeting.
Endocrinology

Comment On Dimebolin (dimebon) Increasing Brain Beta Amyloid In Mouse Models

Dimebolin, originally administered as an antihistamine, has previously been found to help slow the decline of cognitive ability in participants. This study analysed tau and how dimebolin affects build up of the toxic beta amyloid protein, which is widely believed to be linked to the development of dementia. This research showed that while dimebolin had a beneficial effect it actually caused an increase of the beta amyloid in mouse models. "This head scratching research has thrown up surprising results and suggests that while dimebolin provides cognitive benefits it may actually increase levels of toxic beta amyloid in the brain. One possible explanation may be that dimebolin is accelerating the process of beta amyloid development, which may reduce its toxicity. The questions surrounding whether beta amyloid causes nerve death in Alzheimer"s or is a bi-product of the process must be addressed by further research. "One in three people over 65 will die with dementia. Further, more robust research is needed to clarify whether dimebolin is an effective treatment for Alzheimer"s in the long term and if these puzzling increases in beta amyloid are also seen in human brains. With the right investment, dementia can be defeated. Alzheimer"s Society funds research to improve the lives of people today and to find a cure for tomorrow." Professor Clive Ballard Director of Research Alzheimer"s Society Reference: Samuel Gandy, Dimebon regulates amyloid beta metabolism in cultured cells, isolated nerve terminals and interstitial fluid of living rodent brain. Alzheimer"s Society

Great post, Mason! A fantastic summary/overview. Thanks for the work! Keep going! commented:

Great post! A fantastic summary/overview.
Thanks for the work! Keep going!

16.11.2010


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