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Chemists Explain The Switchboards In Our Cells
Our cells are controlled by billions of molecular "switches" and chemists at UC Santa Barbara have developed a theory that explains how these molecules work. Their findings may significantly help efforts to build biologically based sensors for the detection of chemicals ranging from drugs to explosives to disease markers.

Easy Strength Training Exercise May Help Treat Tennis Elbow, Study Shows
People with pain in the elbow or forearm from playing sports or just from common
News of the day
Understanding How A Drug To Treat Acute Lymphoblastic Leukemia Is Degraded
L-Asparaginase is one of the key drugs used to treat children with acute lymphoblastic leukemia (ALL). However, some children fail to achieve therapeutic levels of L-asparaginase after receiving the drug. The mechanisms underlying such therapeutic failure are not well defined. But now, Vaskar Saha and colleagues, at the Paterson Institute for Cancer Research, United Kingdom, have found that leukemic cells from some patients with ALL express two proteins capable of degrading ASNase, one of the commercially available s of L-asparaginase. Importantly, expression of one of these proteins, AEP, is predominantly observed in individuals with high-risk forms of ALL. By modifying one amino acid of ASNase, the authors were able to render it resistant to cleavage by AEP; however, the modified drug was not as active. The authors hope that this description of a potential mechanism to explain why some children fail to achieve therapeutic levels of L-asparaginase after receiving ASNase will enable optimization of L-asparaginase therapy to the benefit of children with ALL.
Endocrinology

Dietitians Urge Health Ministers To Adopt A National Framework For Home Enteral Nutrition, Australia

Governments could be saving up to $7.88 million a year if they adopt a national home enteral nutrition (HEN) service, according to Australia"s leading nutrition organisation1. The Dietitians Association of Australia (DAA) said access to adequate food and nutrition is a basic human right but many people relying on home tube feeding and nutrition supplements have poor access to the nutrition support they need. And this varies for each State and Territory. DAA CEO Claire Hewat said around 15,000-16,500 home patients access HEN2, due to conditions such as stroke, head and neck cancer, and cystic fibrosis. She described the current HEN services in Australia as "problematic and fragmented", and said this often resulted in compromised patient care and unnecessary hospital readmissions. Ms Sue O"Reilly, parent of HEN patient Shane, said: "Returning to Australia from the United Kingdom, I was shocked and upset to discover how poorly co-ordinated and organised the HEN system is in Australia compared to overseas." Accredited Practising Dietitian (APD) Dr Merrilyn Banks said simple strategies, such as better access to APDs and HEN formula and equipment, can help improve patient health and save health care dollars. "Providing a streamlined and efficient system for HEN will help discharge patients from hospital sooner and prevent readmissions due to HEN-related complications with savings of up to $8 million," said Dr Banks. In its recent submission to the Australian Health Ministers Advisory Council (AHMAC), DAA called for a national framework to address inequities in accessing HEN services across Australia. The Health Policy Priorities Principal Committee, which advises AHMAC, meets on Tuesday to discuss HEN services. DAA is calling on the Ministers to ensure all Australians requiring HEN services for their basic nutrition needs have access to skilled clinical care, such as an APD, and affordable HEN formula and equipment. DAA thanked Nutricia Australia for providing funding to support a project officer to assist DAA members develop the Association"s submission to AHMAC. The Dietitians Association of Australia (DAA) is the professional body representing dietitians nationally. Accredited Practising Dietitian (APD) is the only national credential recognised by the Australian Government, Medicare, the Department of Veterans Affairs and most private health funds as the quality standard for nutrition and dietetics services in Australia. For more information visit http://www.daa.asn.au 1. Towards a National Home Enteral Nutrition Service for patients requiring nutrition support at home, A submission prepared by the Dietitians Association of Australia for the Australian Health Ministers" Advisory Council, 2009. 2. National HEN Survey Results, Dietitians Association of Australia. Dietitians Association of Australia


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