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UCB And Biogen Idec Discontinue Phase II Clinical Trial Of CDP323 - Analysis Showed No Clinically Relevant Benefit For Patients
UCB and Biogen Idec announced today the discontinuation of the Phase II clinical trial of CDP323 for the treatment of relapsing multiple sclerosis (MS). Preliminary interim efficacy analysis showed that patients enrolled in this clinical trial did not benefit as expected from CDP323 compared to placebo after a six month treatment period. No cases of PML (progressive multifocal leukoencephalopathy) were noted.

Nurse Researchers Toil To Curb Spread Of Infectious Disease
Fighting infectious disease, the very heart of public health and the genesis of contemporary nursing, is about more than hand washing and immunizations. It"s about screening and early detection, identifying risk and protective factors, and educating clinicians, facilities and the public. But it all begins with research, like that underway by nurse researchers at the Johns Hopkins University School of Nursing (JHUSON). Their work is more important now than it has been in nearly the past century. Infectious disease rates, stable since the 1918 influenza pandemic, have been on the rise since the mid-1980s. The battle against these illnesses from HIV/AIDS to MRSA and from STDs to resurgent tuberculosis (TB), and others has been escalating, and long before the recent emergence of the H1N1 influenza virus earlier this year.
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Parents Struggle With Costs Of Their Children's Autism Care
The total cost for treating a child with autism can reach $5 million, but insurance companies rarely cover autism therapy and few states mandate it. CBS News reports that "an estimated one in every 150 children in America has autism and the number of reported cases is growing" while "parents are increasingly demanding that insurance companies cover the newest treatment."
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During Pregnancy, Women With Endometriosis Need Special Care To Avoid Risk Of Premature Birth

The largest study to date of endometriosis in pregnant women has found that the condition is a major risk factor for premature birth, the 25th annual conference of the European Society of Human Reproduction and Embryology heard. Dr. Henrik Falconer, of the Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden, said that his team had found that women with endometriosis also had a higher risk of other pregnancy complications, as well as being more likely to give birth through Caesarean section. The research is published on-line in the journal Human Reproduction*. The researchers investigated the association between adverse pregnancy outcome, assisted reproduction technology (ART), and a previous diagnosis of endometriosis in 1 442 675 single births to Swedish women. They found 13 090 births among 8922 women diagnosed with endometriosis. Compared with women without endometriosis, they had a 1.33 greater risk of preterm birth. Women with endometriosis were also more likely to have difficulty in conceiving and need to receive ART, which is itself a risk factor for adverse pregnancy outcome. Among women with endometriosis, 11.9% conceived after ART compared with the 1.4% of women without endometriosis who used the technique. The risk of preterm birth associated with endometriosis among women with ART was 1.24, and among women without ART 1.37. "Endometriosis appears to be a risk factor for preterm birth, irrespective of ART," said Dr. Falconer. "Our findings indicate that women with endometriosis may be considered a high risk group and have special care during pregnancy." Endometriosis is a chronic inflammatory disease, affecting up to 15% of all women of reproductive age, in which the endometrial cells that line the uterus are deposited in other areas. Such displacement of endometrial cells can lead to anatomical distortion and also the release of anti-inflammatory cytokines, signalling molecules used in communication between cells. Symptoms of endometriosis include severe pelvic pain, heavy menstrual periods, and nausea. In addition to an increased risk of preterm birth, the researchers also found other differences in the pregnancies of women with endometriosis. "Nearly twice as many women in this group were delivered by Caesarean section," said Dr. Falconer. "We observed that among these women the risk of induced preterm birth was higher than for spontaneous preterm birth. We believe that women with endometriosis are more frequently scheduled for preterm Caesarean section, possibly due to placental complications." Women with endometriosis were also more likely to suffer from pre-eclampsia, a condition that develops in the second or third trimester of pregnancy and involves the development of high blood pressure and the presence of protein in the urine. Antepartal bleeding was also found to be more common among women with endometriosis, the researchers say. "Because endometriosis is so strongly associated with infertility," said Dr. Falconer, "we were not surprised to find that women suffering from it were of higher maternal age and had fewer children. However, after adjusting for maternal age and other confounding factors, the strong association between endometriosis and risky pregnancies still remained. "Our research provides clinicians with important information in the search for the factors associated with premature birth. Given that endometriosis is relatively common in women of childbearing age, we hope that our results will lead to pregnant women with this condition receiving extra attention, thus enabling them to have normal pregnancies and give birth to healthy babies." *Full paper published in Human Reproduction. doi:10.1093/humrep/dep186 Mary Rice European Society for Human Reproduction and Embryology


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