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HHS Secretary Kathleen Sebelius, Sesame Workshop, And The Ad Council Launch National Campaign To Protect Families From H1N1 Virus And Stay Healthy
Health and Human Services Secretary Kathleen Sebelius announced today that the Department of Health and Human Services (HHS) is joining the Ad Council and Sesame Workshop, the nonprofit educational organization behind Sesame Street, to launch a national public service advertising campaign designed to encourage American families and children to take steps to protect themselves from the 2009 H1N1 flu virus and continue to practice healthy habits. As part of HHS and the Ad Council"s campaign, Sesame Workshop produced a television PSA featuring Sesame Street"s Elmo and Gordon explaining the importance of healthy habits such as washing your hands, avoid touching your eyes, nose and mouth and sneezing into the bend of your arm.

Antidepressants: Preliminary Report Published
Benefit of bupropion proven - Benefit of reboxetine not proven: manufacturer conceals study data
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Low Birth Weight May Mean Higher Risk For Kidney Disease
Parents of newborns who tip the scales at less than 5 ÷½ pounds should put some heavy thought to a possible future consequence: kidney disease. Low birth weight babies have a 70% greater risk of developing chronic kidney disease (CKD) in later life, according to research published in the August issue of the American Journal of Kidney Diseases, the official journal of the National Kidney Foundation.
Public Health

Enhancing The Effects Of Platinum-Based Anti-Cancer Drugs

Daqing Li and colleagues, at the University of Pennsylvania School of Medicine, Philadelphia, have identified in vitro and in mice a way to enhance the anticancer effects of the commonly used platinum-based drug cisplatin. For many forms of cancer, including testicular, ovarian, and lung cancer, platinum-based drugs that cause DNA damage are the first choice treatment. However, the utility of these drugs is often limited by the enhanced ability of cancer cells to repair their DNA. As the MRN protein complex, which contains the protein RAD50, has a key role in the molecular pathways that control DNA repair in human cells, Li and colleagues set out to test the hypothesis that attenuating the function of the MRN protein complex might sensitize cancer cells to the effects of cisplatin. The hypothesis was proven using a genetic approach to disrupt MRN function. Specifically, human squamous cell carcinoma cells resistant to the toxic effects of cisplatin became sensitive to the drug when it was combined with an adenoviral vector that drove expression of a dominant-negative RAD50 protein in the cancer cells. Importantly, the combination therapy had potent anti-cancer cell effects in vitro and in mice transplanted with human squamous cell carcinoma cells resistant to cisplatin. The authors therefore hope that it might be possible to develop a clinical strategy to attenuate MRN function and enhance the anticancer effects of platinum-based drugs. TITLE: Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy https://www.the-jci.org/article.php?id=33816 AUTHOR CONTACT: Daqing Li University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Karen Honey Journal of Clinical Investigation


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