Popular Articles

Instrumental Variable Analysis: Is The Cure Worse Than The Disease?
Causal inference is challenging in all non-experimental studies because of the possibility of hidden bias. Hidden bias may exist as a result of failure to control for unobservable factors, such as doctors" practice/prescription patterns.

FDA Approves TYVASO (Treprostinil) Inhalation Solution For The Treatment Of Pulmonary Arterial Hypertension
United Therapeutics Corporation (Nasdaq: UTHR) announced that the United States Food and Drug Administration (FDA) has approved TYVASO (treprostinil) Inhalation Solution for the treatment of pulmonary arterial hypertension (PAH) using the TYVASO Inhalation System (which includes the Optineb-ir device and accessories). TYVASO is indicated to increase walk distance in patients with NYHA Class III symptoms associated with WHO Group I PAH, which includes multiple etiologies such as idiopathic and familial PAH as well as PAH associated with scleroderma and congenital heart disease.
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NHS Trust Focuses On Staff Health
Hydration expert, Water Wellpoint is playing a key role in helping public sector employers look after the health and wellbeing of their staff. The company has recently been working with East London NHS Foundation Trust to run a series of wellbeing days, giving employees the ability to check key aspects of their health in a total voluntary format.
Nutrition

Link Between Sleep And Weight Control

Could sleep be a critical component to maintaining a healthy body weight? According to new research presented on Sunday, May 17, at the American Thoracic Society"s 105th International Conference in San Diego, body mass index (BMI) is linked to length and quality of sleep in a surprisingly consistent fashion. As part of the Integrative Cardiac Health Project at Walter Reed Army Medical Center, researchers analyzed the sleep, activity and energy expenditures of 14 nurses who had volunteered for a heart-health program at the Walter Reed, where the nurses were employed. The program included nutritional counseling, exercise training, stress management and sleep improvement. Each participant wore an actigraphy armband that measured total activity, body temperature, body position and other indices of activity and rest. "When we analyzed our data by splitting our subjects into "short sleepers" and "long sleepers," we found that short sleepers tended to have a higher BMI, 28.3 kg/m2, compared to long sleepers, who had an average BMI of 24.5. Short sleepers also had lower sleep efficiency, experienced as greater difficulty getting to sleep and staying asleep," said lead investigator Arn Eliasson, M.D. Surprisingly, overweight individuals tended to be more active than their normal weight counterparts, taking significantly more steps than normal weight individuals: 14,000 compared to 11,300, a nearly 25 percent difference, and expending nearly 1,000 more calories a day - 3,064 versus 2,080. However, those additional energy expenditures did not manifest in reduced weight. "We found so many interesting links in our data. It opens up a number of possibilities for future investigation," said Dr. Eliasson. "Primarily, we want to know what is driving the weight differences, and why sleep and weight appear to be connected." He postulates that getting less sleep might disrupt natural hormonal balances - for example, reducing the amount of leptin, otherwise known as the satiety hormone - and could thereby cause those individuals to eat more. Stress may also play a role in both reducing the length and quality of sleep and increasing eating and other behaviors that may result in weight gain. "Higher perceived stress may erode sleep. Stress and being less rested may cause these individuals to be less organized than normal weight individuals, meaning they would have to make more trips and take more steps to accomplish the same tasks. This might add to their stress and encourage other unhealthy behaviors like stress eating," said Dr. Eliasson. "It would be fascinating to know the results of a carefully designed study that controlled for the many influences on weight gain, while varying sleep parameters and measuring hormonal mediators of appetite and metabolism," said Dr. Eliasson. "We are planning further studies to evaluate the role of stress in sleep and metabolism." Keely Savoie American Thoracic Society


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