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UCF Team's Advanced Nerve Cell System Could Help Cure Diabetic Neuropathy, Related Diseases
Multiple sclerosis, diabetic neuropathy, and other conditions caused by a loss of myelin insulation around nerves can be debilitating and even deadly, but adequate treatments do not yet exist. That"s in large part because of deficiencies in model research systems. In an upcoming issue of the journal Biomaterials, a UCF team addresses this problem with a report on the first lab-grown motor nerves that are insulated and organized the same way they are in the body. The group"s model system, along with further advances now within reach, could dramatically improve understanding of the causes of myelin-related conditions, and enable discovery and testing of new drug therapies.

IRIN Examines PEPFAR Funding Of IDU Programs
IRIN examines a recent comment piece in the journal Lancet that argues PEPFAR can do more to prevent the spread of HIV among injecting drug users (IDUs) in Africa (IRIN, 6/24). Although PEPFAR has helped to provide "antiretroviral therapy to 2.1 million people with HIV, almost all of whom live in sub-Saharan Africa, and has spent more than $18 billion on the continent," it has failed to reach "thousands of injecting drug users in PEPFAR countries in Africa, many of whom have HIV," according to the authors of the Lancet article (Kaiser Global Health Policy Report, 6/19).
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Fathers Respond To Teens' Risky Sexual Behavior With Increased Supervision
Two-thirds of American teenagers have sex by the time they"re 18. A new longitudinal study finds that when adolescents engage in risky sexual activity, fathers respond by increasing their efforts to supervise and monitor their children.
Sexual Health

Signature Genomic Laboratories Detects Chromosome Abnormalities In Individuals With Genetic Disorders Associated With Susceptibility To Cancer

Geneticists at Signature Genomic Laboratories recently demonstrated that microarray-based genetic testing can identify chromosome abnormalities that cause genetic disorders associated with susceptibility to cancer prior to the onset of symptoms. In their study, published in the May issue of Genetics in Medicine, geneticists from Signature reviewed data from 18,437 individuals who were tested by microarray analysis for unexplained mental retardation and congenital anomalies. DNA copy number gains or losses that encompassed gene regions associated with recognized genetic conditions with an increased risk for cancer were identified in 34 individuals. Almost three-quarters of those individuals had indications for study that were not specific to the diagnosed syndrome and therefore presumably did not have signs of cancer. The authors describe multiple instances in which early diagnosis improved medical management of the patient and allowed for early surveillance of cancer onset. "It is well known that microarray analysis allows for diagnosis of genetic syndromes at an early age that otherwise may not be diagnosed until onset of symptoms later in life," said Dr. Bassem A. Bejjani, M.D., Chief Medical Officer of Signature and senior author of the study. "However, this study shows the impact of early diagnosis is even more profound when a syndrome is associated with childhood-onset cancer, in which the threat of cancer is added to the child"s other medical issues." Signature Genomic Laboratories, LLC


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