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Discovery Of Molecular Cause Of Alzheimer's Disease Could Bring Early Diagnosis, Treatment Closer
A discovery made by researchers at McGill University and the affiliated Lady Davis Research Institute for Medical Research at Montreal"s Jewish General Hospital offers new hope for the early diagnosis and treatment of Alzheimer"s disease.

Some Blood Pressure Drugs May Help Protect Against Dementia
A particular class of medication used to treat high blood pressure could protect older adults against memory decline and other impairments in cognitive function, according to a newly published study from Wake Forest University School of Medicine.
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Osiris Therapeutics Reports Interim Data For COPD Stem Cell Study
Therapeutics, Inc. (NASDAQ:OSIR) announced six-month interim data from a Phase II clinical trial evaluating Prochymal, the Company"s proprietary formulation of adult mesenchymal stem cells, for the treatment of chronic obstructive pulmonary disease (COPD). Sixty-two patients were enrolled and are being followed for two years in the placebo-controlled study. At the six-month time-point, the data revealed several important findings.
Mental Health

Stromal Marker For Breast Cancer Progression Identified

Dr. Arne Ostman and colleagues at the Karolinska Institutet in Stockholm have identified a stromal marker for breast cancer progression. They present these findings in the July 2009 issue of the American Journal of Pathology. Platelet-derived growth factor (PDGF) receptors are involved in multiple stages of cancer cell growth. However, the contribution of PDGFR expression in the stroma, or surrounding supportive tissue, of the tumor remains unclear. Paulsson et al therefore characterized PDGFR expression in stroma of various tumors, including lymphoma and colon, ovarian, prostate, lung, and breast cancer. They found highly variable PDGFR expression in solid tumors, with colon and prostate tumors expressing the highest stromal levels of one type of PDGFR, PDGFí²R. In breast cancer, stromal PDGFí²R expression in pre-menopausal breast cancer patients significantly correlated with negative prognosis. These data highlight the importance of examining stromal as well as malignant cell expression of PDGF receptors in disease prognosis. Paulsson et al suggest that "the findings in the present study of robust staining procedures for PDGF receptors should motivate continued studies of the response-predicative value of stromal PDGF receptor status." Paulsson J, Sjö¶blom T, Micke P, Pontö©n F, Landberg G, Heldin C-H, Bergh J, Brennan DJ, Jirströ¶m K, ö-stman A: Prognostic significance of stromal PDGF í²-receptor expression in human breast cancer. Am J Pathol 2009, 174: 2752-2764 Angela Colmone American Journal of Pathology

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