Medical Devices
Oculus Innovative Sciences, Inc. (NASDAQ:OCLS), a healthcare company that develops, manufactures and markets a family of products based upon the Microcyn® Technology platform, which includes new formulations intended to reduce the use of antibiotics by preventing or treating infections including those caused by bacteria and viruses, has confirmed the effectiveness of Microcyn® Technology at inactivating the H1NI Swine Influenza A. In a virucidal time-kill suspension test conducted by an independent laboratory, BioScience Laboratories, Inc., the specific Microcyn Technology formulation reduced infectivity of the swine flu virus by 4.00log10 (99.99%) reduction after just 30-seconds exposure. BioScience Laboratories, working in cooperation with the U.S. Department of Agriculture, received formal approval to acquire, house and evaluate the specific swine influenza virus in April 2009.
National Community Pharmacists Association (NCPA) Executive Vice President and CEO, Bruce T. Roberts, RPh testified today before the U.S. House Energy and Commerce Subcommittee on Health, offering four different recommendations to strengthen a health care reform proposal currently working its way through Congress.
Vision loss costs Canadian society a staggering $15.8 billlion per year - significantly higher than previously estimated, according to new research study released on June 23, 2009, by CNIB and the Canadian Ophthalmological Society (COS). The study"s proponents say these costs, which are expected to increase dramatically in the years ahead, underscore the urgent need for Canada to develop a comprehensive national vision health plan.
Quantitative assessments of patient quality of life are becoming increasingly important in the context of clinical trials. In addition to establishing benchmark score differences that are useful when interpreting study results, Minimal Important Differences (MIDs) inform discussions of clinically meaningful change in patient status.
The Associated Press reports on the costs of disease prevention: "When it comes to health care spending, an ounce of prevention is seldom worth a pound of cure. ...The truth is, shockingly few prevention efforts actually save the health care system money overall, despite claims by the president and some in Congress."
A Lifeline For Primary Care The New England Journal of Medicine
A three-year initiative launched last year by the New York City Department of Health and Mental Hygiene to test every adult in the Bronx for HIV has boosted testing by 28 percent, according to city health officials, the New York Times" blog "City Room" reports. The "Bronx Knows" campaign began with an effort to make voluntary HIV testing routine in emergency departments and clinics, where city officials said, "cumbersome consent procedures required by state law have deterred doctors from offering the tests," according to "City Room" (Chan, "City Room," New York Times, 6/24). The initiative - which involves clinics, hospitals and community organizations - tested nearly 160,000 Bronx residents in the past 12 months (United Press International, 6/24). The city also is participating in National HIV Testing Day on Saturday ("City Room," New York Times, 6/24).
Polk County, Fla., health officials have made educating the black community a top priority in addressing HIV/AIDS in the state, where blacks are disproportionately affected by the virus, the Lakeland Ledger reports. The Polk County Health Department has expanded its community outreach and testing efforts to different types of settings such as beauty salons, community centers and churches. County outreach workers hope that offering education and screening in such settings will encourage residents to get informed and tested for HIV (Williams Adams [1], Lakeland Ledger, 6/24). In addition, the Ledger examined the complex issues the black community faces with regard to HIV/AIDS and the barriers that need be addressed to reduce the impact of HIV/AIDS on minorities (Williams Adams, Lakeland Ledger, 6/25). The Ledger also profiled Bonnie Munson, a local resident who performs volunteer outreach efforts in her community, including distributing condoms and informational material to other residents (Williams Adams [2], Lakeland Ledger, 6/24).
The following summarizes recent editorials and opinion pieces responding to health reform action over the last week.
The Healthcare Association of New York State (HANYS) presented its 2009
Reviewing the records of 577 breast cancer patients, Fox Chase Cancer Center researchers found that women with newly diagnosed breast cancer who receive a breast MRI are more likely to receive a mastectomy after their diagnosis and may face delays in starting treatment. The study demonstrates that, despite the lack of evidence of their benefit, routine use of MRI scans in women newly diagnosed with breast cancer increased significantly between 2004 and 2005, and again in 2006.
President Barack Obama"s signature on a bill this week to grant the Food and Drug Administration (FDA) regulatory authority over tobacco was historic, and represents a step in the march to eliminate tobacco use in this country by 2047, two national tobacco experts said recently (June 25).
People in very early stages of Alzheimer"s disease already have trouble focusing on what is important to remember, a UCLA psychologist and colleagues report.
UCB announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending that the European Commission grants a marketing authorisation for Cimzia® (certolizumab pegol), in combination with methotrexate (MTX), for the treatment of moderate to severe active rheumatoid arthritis in adult patients when the response to disease-modifying anti-rheumatic drugs (DMARDs) including MTX, has been inadequate. In these patients, Cimzia® can be given as monotherapy in case of intolerance to MTX or when continued treatment with MTX is inappropriate. Cimzia® has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function, when given in combination with MTX.
Researchers at the Intermountain Medical Center have conducted research into the link between atrial fibrillation, a fairly common heart rhythm disorder, and dementia. The study of more than 37,000 shows that patients with atrial fibrillation were 44% more likely to develop dementia than patients without the disorder.
Childhood physical abuse is associated with elevated rates of cancer in adulthood, according to a new study by University of Toronto researchers.
The American Association of Kidney Patients (AAKP) is very disappointed with Wanda Sykes" comedic comments regarding kidney failure and Rush Limbaugh at the White House Correspondent Dinner over the weekend. While Ms. Sykes" comments were most likely made in a light-hearted manner, hundreds of thousands of kidney disease patients and their loved ones do not see kidney failure as a laughing matter. Nearly 400,000 Americans are receiving dialysis as a life saving treatment for kidney failure and 26 million Americans have been diagnosed with chronic kidney disease (CKD), which means they are at risk for losing their kidney function. In addition, 20 million Americans are at risk for CKD and do not even know it.
The Agency for Healthcare Research and Quality"s annual release of state-by-state quality data continues to give states mixed reviews for the quality of care they provide. As in previous years, AHRQ"s 2008 State Snapshots show that no state does well or poorly on all quality measures.
Today the Lance Armstrong Foundation (LAF) announced outstanding new commitments to cancer control from European nations including Belgium, England, Germany, Ireland and Italy as part of the LIVESTRONG Global Cancer Campaign, an initiative to address the global cancer burden. The European commitments feature ambitious goals ranging from creating a national cancer plan to addressing disparities in treatment for cancer survivors to establishing an academy devoted entirely to cancer to improvements for breast health services, among others.
Boehringer Ingelheim announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending the approval of a once daily formulation for Mirapexin®/ Sifrol® (pramipexole), in all countries of the European Union, Norway, Iceland and Liechtenstein. The CHMP recommendation states that the new prolonged-release formulation is indicated for treatment of the signs and symptoms of idiopathic Parkinson"s disease, alone (without levodopa) or in combination with levodopa, i.e. over the course of the disease, through to late stages when the effect of levodopa wears off or becomes inconsistent and fluctuations of the therapeutic effect occur (end of dose or "on off" fluctuations).
HearAtLast Holdings, Inc. (PINKSHEETS: HRAL), a leading provider of suitable affordable solutions to clients with hearing needs in the billion dollar hearing loss market, announced that in keeping with its tradition of bringing innovative new products to consumers, the Company announces the unveiling of breakthrough hearing products based on the Neuro-Compensator™ algorithm technology from VitaSound Audio.
An additional 535 confirmed human cases of Swine Flu A(H1N1) cases have been confirmed in the England, plus 111 in Scotland, 5 in Northern Ireland, and 3 in Wales, bringing the UK total so far since April 2009 to 4,250, says the Health Protection Agency (HPA). The HPA informs that the infection can be effectively treated with antiviral medication. The majority of UK cases have been mild, the agency says, and people have recovered fully after treatment.
Pope Benedict XVI has agreed to meet with President Obama at the Vatican on July 10, according to White House spokesperson Robert Gibbs, the AP/Boston Globe reports. The Rev. Federico Lombardi, a Vatican spokesperson, on Wednesday said that the pope will hold an afternoon meeting with the president and first lady Michelle Obama after the conclusion of the Group of Eight industrialized nations summit meeting, a break with a Vatican tradition of holding midday meetings. The AP/Globe reports that the Vatican "clearly sought to accommodate" the president"s schedule, an indication that Benedict is interested in meeting with Obama despite his support for abortion rights and embryonic stem cell research.Some U.S. bishops have publicly attacked Obama"s support of abortion rights and embryonic stem cell research, which has fueled anticipation of a meeting between the president and the pope. Most recently, dozens of bishops denounced the University of Notre Dame"s decision to invite Obama to deliver its commencement address and receive an honorary degree. However, L"Osservatore Romano, the Vatican"s daily newspaper, said that Obama"s speech showed that he is looking for common ground on issues related to abortion. Obama also received a positive review from the newspaper after his first 100 days in office. An editorial in the paper said that Obama had not confirmed the "radical" direction on ethical questions he had discussed as a candidate (Simpson, AP/Boston Globe, 6/24).
Women who have depression symptoms prior to becoming pregnant are at an increased risk for having preterm births, with the risk twice as high for black women as for white women, according to a study in the Journal of Women"s Health, Reuters reports. For the study, Amelia Gavin of the University of Washington and colleagues examined the links between race, preterm birth and pre-pregnancy depressive mood among 555 women. The study used data collected from 1990-1996 as part of a larger, long-term investigation of heart disease risk.Researchers determined that 18.1% of the 249 black women in the study gave birth prior to 37 weeks" gestation, compared with 8.5% of the 306 white women in the study. The study also found that 9.4% of black women had pre-pregnancy symptoms of depressive mood, compared with 7.2% of white women. After researchers accounted for other factors associated with preterm birth, such as body weight and sociodemographic characteristics, black women"s risk remained more than twice that of white women.Gavin said, "The black-white disparity in preterm birth may be in part a consequence of different exposures to depressive mood prior to pregnancy." She said, "Reproductive outcomes must be viewed in light of women"s health over the entire life-course, as well as during pregnancy," adding that the study"s results suggest that "the experience of cumulative health disadvantages or "weathering"" might play a role in increased risk for preterm birth (Hendry, Reuters, 6/25).
In malaria-endemic areas, vitamin A supplements - which cost about 2 U.S. cents each - can help reduce infections in children by one-third, according to a study published in the Malaria Journal, IRIN reports. The study analyzed results from previous studies conducted in Burkina Faso, Ghana and Papua New Guinea since 1995. It found that vitamin A supplements decreased malaria cases by one-third in Papua New Guinea and Burkina Faso.
The efficacy of preimplantation genetic screening (PGS) has been one of the most hotly disputed subjects in assisted reproduction over the past few years. None of the trials carried out so far has shown conclusively whether it works or not. Now the European Society of Human Reproduction and Embryology (ESHRE) Task Force on PGS has decided to try to find out if a novel method of doing PGS using polar body biopsy and chromosome array analysis offers a possible solution.
Gonorrhea (from Late Latin gonorrhoia where gonos means "seed" and rhoe means "flow") is a sexually transmitted bacterial infection that tends to attack the mucous membranes of the body. It is the second most common sexually transmitted disease in the U.S.; the first being Chlamydia. The bacteria reside in the warm and moist body cavities of both men and women and are highly contagious. Gonorrhea is the most common cause of female infertility and is also known as "the clap" or "the drip". Only a fraction of women infected with the disease show any symptoms, leaving them unaware of their condition. If left untreated, gonorrhea patients can develop pelvic inflammatory disease or PID (women), or an inflammation of the epididymis, prostate gland, or urethral structure (men), all of which are far more difficult to treat.
Southampton"s teaching hospitals have been recognised by one of the UK"s top medical organisations for leading the way in use of antibiotics in the fight against infection. The British Medical Association, the professional body for doctors and medical students, praised Southampton University Hospitals NHS Trust"s development of clear and simple antimicrobial prescribing guidelines for staff.
Health and social care services are overlooking the long-term physical and emotional effects of cancer survivors, leaving many of the two million people living with or beyond the disease in the UK suffering alone and in silence. According to Macmillan Cancer Support, cancer survivors are suffering needlessly and in silence: overlooked by health and social care services that frequently miss the long-term physical and emotional effects of the disease.
Draft proposals by the Productivity Commission designed to reduce the red tape burden on medical practices will benefit patients, the AMA said today.
The AMA has written to Federal MPs and Senators urging them to support a number of key policy measures to reduce preventable health problems linked to excessive alcohol use, obesity and smoking.
GI Dynamics, a leader in non-surgical treatments for type 2 diabetes and obesity, today announced results from a pilot clinical study which demonstrated the substantially enhanced weight loss effects of combining the company"s EndoBarrier Gastrointestinal Liner with a new EndoBarrier Flow Restrictor. The EndoBarrier Flow Restrictor provides an adjustable restriction at the outlet of the stomach and is designed to delay gastric emptying, an additional mechanism which adds to the therapeutic effects of the liner. The results were presented today at the 26th annual meeting of the American Society for Metabolic and Bariatric Surgery (ASMBS).
The American Pharmacists Association (APhA) will publish in mid-July the second edition of Pagliaros" Comprehensive Guide to Drugs and Substances of Abuse. Written by veteran authors Louis A. Pagliaro and Ann Marie Pagliaro, the reference includes more than 100 monographs-11 of them new-dealing with each of the major drugs and substances of abuse used in North America, from acetone to zopiclone.
Diabetelogia, the journal of the European Association for the Study of Diabetes (EASD), published a series of research papers today examining a possible link between insulin glargine (brand name, Lantus) and cancer. Findings from these research papers are conflicting and inconclusive, and the American Diabetes Association cautions against over-reaction until more information is available.
Because tobacco use impairs military readiness, harms the health of soldiers and veterans, and imposes a substantial financial burden on the departments of Defense and Veterans Affairs, these agencies should implement a comprehensive strategy to achieve the Defense Department"s stated goal of a tobacco-free military, says a new report from the Institute of Medicine. DOD should gradually phase in a ban on tobacco use in the military, starting at military academies and officer training programs and among new recruits, the report says. DOD should also stop selling tobacco products in Army and Air Force commissaries -- Navy and Marine Corps commissaries already do not sell them -- and should stop selling them at a discount in military exchanges and other stores. In addition, Congress should allow VA to establish tobacco-free medical centers.
Plainview Milk Products Cooperative, Plainview, Minn., is voluntarily recalling instant nonfat dried milk, whey protein, fruit stabilizers, and gums (thickening agents) that it has manufactured over the past two years, because they might be contaminated with Salmonella. The company sells these products to other industry customers, including distributors and manufacturers, who may have incorporated them into their own products. None of Plainview"s products were sold directly to the public.
Biolex Therapeutics, Inc. announced that it has completed patient enrollment in the SELECT-2 Phase 2b trial of its lead product candidate Locteron® for the treatment of chronic hepatitis C. Locteron, controlled-release interferon alpha 2b, is designed to improve patient care by providing a more convenient once-every-two week dosing schedule and by reducing the side effects, including flu-like symptoms, associated with pegylated interferons, the current standard of care.
Medtronic, Inc. announced that DFine Europe GmbH has accepted the terms of a preliminary injunction granted to Medtronic GmbH by a German Competition Court. The preliminary injunction stops DFine Europe GmbH from using certain misleading marketing claims related to Medtronic"s Kyphon® Balloon Kyphoplasty products in Germany.
UNISON and UNITE are calling on North Somerset Council to put a stop to plans to privatise transport services, warning that outsourcing could put vulnerable young children at risk.
Yaupon Therapeutics, a privately held specialty pharmaceutical company, has announced it has completed enrollment for a pivotal Phase 2 clinical trial for Clearazide for the treatment of early-stage cutaneous T-cell lymphoma (CTCL - stages 1-2a). The study, which is being conducted under a Special Protocol Assessment (SPA) with the FDA, has enrolled 260 patients in 13 of the top cancer centers in the US. Yaupon expects the last patient to complete treatment in the study by June of 2010 and, assuming positive results, will file its NDA shortly thereafter.
Commenting on the health announcements contained in Building Britain"s Future, The King"s Fund chief executive Niall Dickson said: "The idea that patients should have a right to certain standards of treatment is a good one and the government should be congratulated on reducing the number of central targets, some of which were hard to justify. However, we do need to be clear that many of the "rights" set out in the Prime Minister"s announcement are currently "must do"s" for the NHS. For example, the four hour maximum wait in accident and emergency, the 18 week wait for hospital treatment and health checks for 40 year olds are all already in operation.
In a leading medical journal this week US researchers describe the 90-year history of swine flu and warn about working with "freezer" viruses,
Despite costs and public skepticism, Democrats are increasingly confident that they"ll enact a vast health care overhaul. McClatchy reports: "The White House is ramping up its behind-the-scenes lobbying of Congress. President Barack Obama is signaling that he could drop some key principles of his campaign if necessary to jump-start negotiations, opening the door to broad tax increases and a plan that could, he now concedes, push people into a government-run insurance program against their will. Senate Democrats also said last week that they were heading toward agreement again after a momentary stall. ... Republicans, too, concede that the Democrats who control Congress and the White House are back on track to push an overhaul into law."
A new report finds that "a growing global trade in black market cigarettes is killing tens of thousands of people a year, causing massive health problems and costing governments billions of pounds," the Guardian reports.
Fox News examines a U.S.-supported program in Iraq that is equipping women with the skills they need to become nursing aids.
At the annual meeting of the American Optometric Association (AOA), members voted Friday 1,126 to 887 in favor of establishing the American Board of Optometry (ABO) as the entity to develop and implement the framework for board certification and maintenance of certification.
Biovail Corporation (NYSE: BVF)(TSX: BVF) announced that the Company has received the 2009 Corporate Award from the National Organization for Rare Disorders (NORD) for the development of Xenazine® for the treatment of chorea in association with Huntington"s disease. The Award was presented last night at NORD"s Partners in Progress Gala in Washington D.C.
The decision to use expensive cancer therapies that typically produce only a relatively short extension of survival is a serious ethical dilemma in the U.S. that needs to be addressed by the oncology community, according to a commentary published online June 29 in the Journal of the National Cancer Institute.
New HIV therapies have prolonged lives and improved health for patients with HIV, but the treatments have also brought the longer-term effects of the disease into sharper focus.
Pancreatitis is often a fatal condition, in which the pancreas digests itself and surrounding tissue. Scientists have previously found that alcohol can trigger the condition by combining with fatty acids in the pancreas, which leads to an excessive release of stored calcium ions. Once calcium ions enter cell fluid in the pancreas it activates digestive enzymes and damages the cells.
The current H1N1 swine flu strain has genetic roots in an illness that sickened pigs at the 1918 Cedar Rapids Swine Show in Iowa, report infectious disease experts at the University of Pittsburgh Graduate School of Public Health in the New England Journal of Medicine. Their paper, published online and slated for the July 16 print issue, describes H1N1"s nearly century-long and often convoluted journey, which may include the accidental resurrection of an extinct strain.
New research from the University of North Carolina at Chapel Hill School of Medicine finds that aerobic activity may keep the brain young.
A Kansas State University researcher is studying the potential health benefits of a specially bred purple sweet potato because its dominant purple color results in an increased amount of anti-cancer components.
In a study with important consequences for studies on the effects of chemicals on steroid responses in humans, a team of French and American scientists, including Michael E. Baker, PhD, professor in UC San Diego"s Department of Medicine, Division of Nephrology-Hypertension, have found that - contrary to earlier assumptions - enzymes used for the synthesis of steroids in insects, snails, octopuses and corals are unrelated to those used in humans.
Despite results which show patients are very happy with access to their GP, this year"s patient survey will result in millions of pounds being lost to general practice, potentially damaging attempts to improve GP access, the BMA said yesterday (Tuesday 30 June 2009). This year"s patient access survey results published today found nine in ten (91%) of patients were satisfied with the care they received at their surgery, nearly 17 out of 20 (84%) could get an appointment within 48 hours, and three quarters (76%) were able to book an advanced appointment. It is not possible to compare this year"s results with previous years" because the wording of the questions has changed.
New data from an economic analysis presented today at this year"s European Society of Human Reproduction and Embryology (ESHRE) congress showed that, within the parameters of the simulation model used, the in vitro fertilisation (IVF) treatment MENOPUR (highly-purified human menopausal gonatropin or HP-hMG) offered considerable cost-savings over recombinant follicle stimulating hormone (rFSH).1 The cost-effectiveness of HP-hMG compared with rFSH suggested by this data could make it a more attractive choice for use in infertility treatment within a fixed healthcare budget.
The British Veterinary Association (BVA) has called on Defra to abandon its plans for a new animal health body that will give responsibility for animal health to an independent board and leave responsibility for animal welfare with ministers. The BVA has also expressed deep concerns over the confusion caused by the new structure that could lead to delays in dealing with outbreaks of disease across the UK.
Lower extremity peripheral arterial disease (PAD) affects more than eight million Americans, with significant risks of limb loss, disability and death. Treatment of lower extremity PAD focuses on restoring normal blood supply to the affected limb. Traditional treatment, such as surgical bypass, is effective but invasive. In recent years, many patients have been treated with newer endovascular interventions, using catheter-based devices to reopen peripheral arteries in a less-invasive fashion. According to past research, it is unclear if these newer treatments are as effective as conventional surgical bypass in preventing amputation.
Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced today it has established a new collaboration with the National Microbiology Laboratory of the Public Health Agency of Canada and the University of Pennsylvania to further evaluate Inovio DNA vaccine candidates against swine influenza A (H1N1) virus. As a part of its universal influenza vaccine program, Inovio has designed and manufactured consensus DNA vaccines for H1N1 influenza strains. These consensus vaccines, delivered using Inovio"s proprietary electroporation technology, have the potential to provide protection against a broad scope of existing as well as currently unknown, unmatched influenza strains that could emerge -- one of the perpetual challenges in trying to protect against influenza. The purpose of this collaboration is to test these vaccine candidates against pandemic and seasonal influenza strains in animal models and will include testing against a recently identified swine H1N1 strain.
Somerset Partnership NHS Foundation Trust has announced the appointment of a new Non Executive Director to its Board.
The Damon Runyon Cancer Research Foundation named 4 new Damon Runyon Clinical Investigators at its April 2009 Clinical Investigator Award Committee review. The recipients of this prestigious, three-year award are outstanding early career physician-scientists conducting patient-oriented cancer research at major research centers under the mentorship of the nation"s leading scientists and clinicians. Each will receive $450,000 to support the development of his cancer research program.
NPR interviewed Robert Reich, professor of public policy at the University of California at Berkeley and former Secretary of Labor in the Clinton administration, on the steps President Barack Obama needs to take to successfully reform health care. Recently, Reich sent Obama a memo "outlining six things the president must to do save universal health care." Reich told NPR that "health care is stalling in the Senate," and Obama must "fire people up" and "be tough" to counter the medical industry, which has "some of the most formidable lobbies in the country." Reich said that Obama is only going to succeed if he "counts noses, cajoles, twists arms, threatens - and I think he does have it in him." He adds that while "bipartisanship is a noble aspiration," "we"re getting to the point where the president has got to say if I do not get your votes on this, Republicans, I"m going to go through reconciliation. I"m going to do it without you" (Martin, 6/29).
GPs and practice managers still face familiar barriers when it comes to making one of the government"s flagship health policies a success, yet many remain optimistic that practice-based commissioning (PBC) can make a difference to patient care.
Oxfam Calls On G8 Leaders To Increase Agriculture Investment In Developing Countries
Responding to the publication of Lord Darzi"s report, High Quality Care for All: Our Journey So Far, Dr Peter Carter, Chief Executive & General Secretary of the Royal College of Nursing (RCN), said:
The American Institute of Ultrasound in Medicine (AIUM) has reached a management agreement with the International Society for Therapeutic Ultrasound (ISTU) effective July 1, 2009. The AIUM will support the ISTU"s administrative, financial, and member service functions in an effort to maximize the ISTU"s mission of advancing therapeutic ultrasound applications worldwide.
A minimally invasive procedure to treat tendonitis in the rotator cuff of the shoulder provides immediate symptom relief to the patient, according to a study published in the July issue of Radiology. The study found that ultrasound-guided nonsurgical therapy significantly reduces pain from calcific tendonitis of the rotator cuff and restores lasting mobility after treatment.
UCB and Biogen Idec announced the discontinuation of the Phase II clinical trial of CDP323 for the treatment of relapsing multiple sclerosis (MS). Preliminary interim efficacy analysis showed that patients enrolled in this clinical trial did not benefit as expected from CDP323 compared to placebo after a six month treatment period. No cases of PML (progressive multifocal leukoencephalopathy) were noted.
It is based on detecting short, repetitive DNA segments in the genome of bacteria. Every single bacterial strain has such characteristic repeats. "With this method we are able to identify bacterial strains as well as clarify their genetic relationships. Furthermore, we can show how new pathogenic variants develop," says Manfred Hç¶fle, researcher at the HZI. The results have now been published in the current issue of the scientific journal Applied and Environmental Microbiology. The work is part of the two European Union funded projects "Healthy Water" and "AQUA-chip". Manfred Hç¶fle is coordinator of both projects that deal with various aspects of the microbiological safety of both, drinking water and sea water.
Each year in this country, one of every three people over age 65 suffers a fall, resulting in nearly 16,000 deaths. The federal government estimates that 1.8 million older adults who fall are treated each year in hospital emergency rooms for nonfatal injuries - including bruises, fractures and head trauma - and that 433,000 of those individuals need to be hospitalized because of their injuries. Research published this month in the Journal of the American Geriatrics Society has found that a significant number of those falls - an average of 129 per day - involve the use of walkers and canes, the very devices on which millions rely to help them avoid the dangers posed by falling.
A new report issued by the International Osteoporosis Foundation (IOF) and published in the scientific journal Osteoporosis International1, shows that populations across the globe are suffering from the impact of low levels of vitamin D. The problem is widespread and on the increase, with potentially severe repercussions for overall health and fracture rates.
Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbr̿ck Center for Molecular Medicine (MDC) Berlin-Buch and Charit̩ - University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases. In the future, their findings may help identify patients with aggressive tumors at an earlier stage (Gastroenterology 2009, doi:10.1053/j.gastro.2009.03.041).*
There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity.
AMAG Pharmaceuticals, Inc. (NASDAQ:AMAG) announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Feraheme™ (ferumoxytol) Injection for intravenous (IV) use as an iron replacement therapy for the treatment of iron deficiency anemia in adult patients with chronic kidney disease. The recommended dose of Feraheme is an initial 510 mg IV injection followed by a second 510 mg IV injection three to eight days later. Feraheme should be administered as an undiluted IV injection delivered at a rate of up to 1 mL/sec (30 mg/sec). The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia.
The largest study of the genetics of schizophrenia ever undertaken has revealed several new common single-letter variants in the sequence of the human genome (SNPs) linked to risk of the disease. The study, by a multinational consortium of scientists led by a team from deCODE genetics (Nasdaq: DCGN), analyzed the genomes of more than 50,000 patients and control participants from fourteen countries. It is published today in the online edition of Nature.
Many low-income women are failing to take the hormonal therapy prescribed as part of their breast cancer treatment, possibly lowering their survival rates, according to a study led by a researcher in the Duke Comprehensive Cancer Center.
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga.
AstraZeneca announced that it has received a licence by the European Medicines Agency (EMEA) for its oral targeted anti-cancer drug, gefitinib, for EGFR (epidermal growth factor receptor-tyrosine kinase) activating mutation positive patients with Non Small Cell Lung Cancer (NSCLC). NSCLC is the most common type of lung cancer and accounts for 80% of all lung cancer cases. [1] The licence means that for the first time, thousands [2] of patients undergoing first line treatment of NSCLC in the UK may benefit from a more effective, [3] oral alternative to doublet chemotherapy (UK standard of care) without many of the side effects associated with chemotherapy. [3]
During today"s White House online town hall on health care, a question was submitted by Congressman Michael C. Burgess, M.D. (R-Texas), Chairman of the Congressional Health Care Caucus. Following President Obama"s response to the question on medical liability reform, Congressman Burgess issued the following statement:
Complications during pregnancy may increase the risk of having a child with autism, according to American researchers.
The pharmaceutical company Roche on Wednesday announced a program to help ensure developing countries have access to its antiviral Tamiflu, for "the management of a novel influenza strain defined by the WHO as having significant and current pandemic potential," Reuters reports (Egenter, 7/1). The program will make Tamiflu, which has been shown to be effective against the H1N1 (swine flu) virus, available to developing countries for "half the price normally charged," Dow Jones Newswires/Wall Street Journal reports (Mengewein, 7/1).
Mental health charity Mind has announced that Times journalist Sathnam Sanghera has won this year"s Mind Book of the Year Award for "The Boy with the Topknot: a memoir of love, secrets and lies in Wolverhampton" (1). The memoir is about growing up in Wolverhampton and retrospectively discovering at the age of 24 that both his father and sister had schizophrenia.
NARAL Pro-Choice America on Monday announced its endorsement of appointed Sen. Kirsten Gillibrand (D-N.Y.) in her bid for a full term in 2010, Politico reports. New York Gov. David Paterson (D) in January appointed Gillibrand to fill the Senate seat vacated by U.S. Secretary of State Hillary Rodham Clinton.NARAL"s political action committee to date has contributed $5,000 to Gillibrand"s campaign, and it plans to organize its more than 63,000 members on her behalf, according a press release from the group. The release calls Gillibrand "a rising star among pro-choice leaders in the Senate." It adds, "She is a resilient campaigner whose fully pro-choice voting record reflects an unwavering commitment to the values of freedom and privacy." NARAL endorsed Gillibrand in her successful 2006 and 2008 House election campaigns (Abrahamson, Politico, 6/30).
There is growing evidence that a procedure for identifying chromosomal abnormalities in embryos prior to in vitro fertilization is ineffective at helping older women become pregnant, the Wall Street Journal reports. The procedure -- known as pre-implantation genetic screening, or PGS -- is performed in dozen of U.S. fertility clinics and sometimes marketed to older women as a way to increase the odds of a healthy live birth. PGS involves extracting a single cell from a six-cell embryo and inspecting it for chromosomal abnormalities known as aneuploidies; unaffected embryos can then be implanted through IVF. Women older than age 35 have a higher risk of aneuploidies, in which embryos have fewer or more than the usual number of 23 pairs of chromosomes. Aneuploidies can trigger early miscarriage or certain genetics conditions, such as Down syndrome. Most medical experts agree that embryo screening is capable of significantly reducing the risk of Down syndrome and other serious chromosome-related illnesses. However, evidence from several studies increasingly suggests that the procedure does not increase older women"s chances of healthy live births. The American Society for Reproductive Medicine released an initial opinion about PGS in 2007, saying that available evidence does not support the use of embryo screening to increase live birth rates in older women. Andrew La Barbera, scientific director of the society, said, "Since that time, there have been several more trials that have reached the same conclusion." Another shortcoming is that most clinics can only test for fewer than half of the 23 chromosomes, meaning that many defects can go undetected. However, medical experts say that the use of PGS has increased in the two years since ASRM issued its recommendations. According to the Journal, PGS can add more than $2,000 to the roughly $10,000 cost of one IVF cycle. Very few health insurers cover PGS, though some pay for IVF. Some experts contend that studies showing a lack of clinical benefit from PGS do not use more efficient biopsy techniques that can prevent damage to the embryo. Santiago Munne, scientific director for Reprogenetics, said that the treatment is "effective." In a 2007 study, Munne and colleagues used PGS to reduce the rate at which patients miscarried. However, the chances of a woman getting pregnant largely were unchanged, which the authors said could be attributed to the small number of study participants (Naik, Wall Street Journal, 6/1).
"In a major break with most other large companies, Wal-Mart Stores Inc. Tuesday told the White House that it supports requiring employers to provide health insurance to workers, a centerpiece of President Barack Obama"s effort to provide near-universal coverage to Americans," The Wall Street Journal reports. "Wal-Mart -- which provides insurance to employees and wants to level the playing field with companies that don"t -- on Tuesday delivered a letter to President Obama taking a different stance." The letter was signed by Wal-Mart Chief Executive Mike Duke, as well as Andrew Stern, president of the Service Employees International Union, and John Podesta, "who led President Obama"s transition team and is chief executive of the Center for American Progress, a liberal-leaning think tank." Wal-Mart"s new stance is "a shift from its previous stance on health-care overhaul and follows years of tussles with organized labor." The Journal adds a caveat: Wal-Mart "isn"t changing its policies. The company says it supports the employer mandate because all businesses should share the burden of fixing the health-care system. ... Wal-Mart"s support for a broad mandate also appears to be aimed at beating back an alternative that may be less favorable to the company. The Senate Finance Committee is considering a measure expected to result in a more burdensome health-insurance requirement for companies that have lower-wage workers" (Adamy and Zimmerman, 7/10).
The drug industry began ramping up its lobbying efforts in 2003, when Medicare Part D began, and now is targeting Democrats.
"Cuts to Medicaid benefits for hundreds of developmentally disabled people in Colorado take effect today, a move that will be devastating, caretakers and advocates say," The Gazette reports. "Annual payments for services such as transportation and work programs are being cut by at least half for about 700 Coloradans with developmental disabilities ... Others will lose a lesser percentage, but some stand to gain financial assistance, said Timothy Hall, deputy executive director for veterans and disability services for the Colorado Department of Human Services."
UCB and Biogen Idec announced today the discontinuation of the Phase II clinical trial of CDP323 for the treatment of relapsing multiple sclerosis (MS). Preliminary interim efficacy analysis showed that patients enrolled in this clinical trial did not benefit as expected from CDP323 compared to placebo after a six month treatment period. No cases of PML (progressive multifocal leukoencephalopathy) were noted.
Johnson & Johnson has announced that Axel Ullrich, Ph.D., director of the Department of Molecular Biology at the Max Planck Institute of Biochemistry in Germany, whose discoveries have led to novel cancer therapies including Herceptin® (trastuzumab) , is the winner of the 2009 Dr. Paul Janssen Award for Biomedical Research. An independent committee of world-renowned scientists selected Dr. Ullrich, who on September 8 will receive a $100,000 prize during a ceremony in Beerse, Belgium.
Being overweight or obese is a leading contributor to cardiovascular disease (CVD) and associated risk factors; however, in patients with established CVD, obesity appears to play a protective role. In fact, data suggest obese patients with heart disease do better and tend to live longer than leaner patients with the same severity of disease, according to a review article published in the May 26, 2009, issue of the Journal of the American College of Cardiology.
A study in the July 1 issue of the journal SLEEP identified a distinct ECG-derived spectrographic phenotype, designated as narrow-band elevated low frequency coupling (e-LFCNB), that is associated with prevalent hypertension, stroke, greater severity of sleep disordered breathing and sleep fragmentation in patients suffering from obstructive sleep apnea (OSA).
The largest study to date of endometriosis in pregnant women has found that the condition is a major risk factor for premature birth, the 25th annual conference of the European Society of Human Reproduction and Embryology heard. Dr. Henrik Falconer, of the Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden, said that his team had found that women with endometriosis also had a higher risk of other pregnancy complications, as well as being more likely to give birth through Caesarean section. The research is published on-line in the journal Human Reproduction*.
Celiac disease, an immune system reaction to gluten in the diet, is over four times more common today than it was 50 years ago, according to findings of a Mayo Clinic study published this month in the journal Gastroenterology.
Treatment with proton pump inhibitors (PPIs) for eight weeks induces acid-related symptoms like heartburn, acid regurgitation and dyspepsia once treatment is withdrawn in healthy individuals, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.
Even under favorable assumptions, including lifelong protection against 70% of all cervical cancers and no side effects, vaccination against the human papillomavirus (HPV) is not cost-effective in the Netherlands, according to a study published online July 1 in the Journal of the National Cancer Institute.
New research, conducted by Charles Wingo and his colleagues, at the University of Florida, Gainsville, suggests a link between the circadian rhythm and control of sodium (salt) levels in mice.
We are all familiar with the fact that cognitive function declines as we get older. Moreover, recent studies have shown that the specific kind of daily activities we engage in during the course of our lives appears to influence the extent of this decline. A team of researchers from Technische Universitç¤t Berlin are studying how division of labour among honey bees affects their learning performance as they age. Surprisingly, they have found that, by switching their social role, aging honey bees can keep their learning ability intact or even improve it. The scientists are planning to use them as a model to study general aging processes in the brain, and they even hope that they may provide some clues on how to prevent them. Dr. Ricarda Scheiner, leader of the research team, presented these findings at the Society of Experimental Biology Annual Meeting in Glasgow.
A team of Penn State scientists has shed light on the processes that lead to certain human DNA mutations that are implicated in hundreds of inherited diseases such as tuberous sclerosis and neurofibromatosis type 1. The results one day could influence the way couples who seek to have children receive genetic counseling. The team, led by Kateryna Makova, an associate professor of biology, also includes Erika Kvikstad, a graduate student in the Department of Biology, and Francesca Chiaromonte, an associate professor of statistics. Their findings will be published in the July 2009 issue of the journal Genome Research.
Ciguatera poisoning, the food-borne disease that can come from eating large, carnivorous reef fish, causes vomiting, headaches, and a burning sensation upon contact with cold surfaces. An early morning walk on cool beach sand can become a painful stroll on fiery coals to a ciguatera victim. But is this common toxin poisoning also the key to a larger mystery? That is, the storied migrations of the Polynesian natives who colonized New Zealand, Easter Island and, possibly, Hawaii in the 11th to 15th centuries? Could ciguatera be the reason masses of people left paradise?
In response to Trust for America"s Health "F as in Fat" report released today, Health Secretary Alfredo Vigil, MD, said New Mexico needs to continue to strengthen its obesity-prevention efforts to address a serious problem with obesity. The report details obesity rates by states and discusses effective state policies and programs.
The U.S. Food and Drug Administration announced that it is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (bupropion). The warning will highlight the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking these drugs.
Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) announced that the U.S. Food and Drug Administration (FDA) has approved Multaq(R) (dronedarone) 400 mg Tablets. Patients with atrial fibrillation (AF) or atrial flutter (AFL) soon will have a new treatment option to help improve current management of their disease. Multaq(R) is the first drug approved in the United States that has shown a clinical benefit to reduce cardiovascular hospitalization in patients with AF/AFL.
Novavax, Inc. (Nasdaq: NVAX) announced its initial agreement to license its proprietary, recombinant virus-like-particle (VLP) vaccine technology to ROVI Pharmaceuticals (Madrid: ROVI) of Spain. ROVI will use the VLP technology to create a comprehensive influenza vaccine solution for the Spanish government under a new 60 million-euro program sponsored and led by the Spanish Ministry of Health and other government groups to develop pandemic and seasonal flu vaccines and establish its only in-border facility. This program, which was announced by Spanish health officials, is being launched to develop safe and effective flu vaccines to serve the entire population of Spain.
Prostate cancer patients who receive brachytherapy and remain free of disease for five years or greater are unlikely to have a recurrence at 10 years, according to a study in the July 1 issue of the International Journal of Radiation Oncology Biology Physics, the official journal of the American Society for Radiation Oncology (ASTRO).
Panel physicians are increasingly offering individual health services (IHS) to patients with statutory health insurance. This is documented by Susanne Richter et al. of the Department of Social Medicine, Lubeck University, in the new edition of Deutsches Arzteblatt (Dtsch Arztebl Int 2009; 106(26): 433-9). IHS include medical health services which are not reimbursed by the health insurance funds and which the patient has to pay for himself.
The second of two reviews in this week´s The Lancet discusses the primary origins of the health gap. In an effort to understand these inequalities, the authors attempt to give an Indigenous perspective. It is the work of Professor Malcolm King, of the University of Alberta, Edmonton, Canada, and Scientific Director, Institute of Aboriginal Peoples" Health (Canadian Institutes of Health Research); Dr Alexandra Smith, of the University of Toronto, Canada; and Professor Michael Gracey, Unity of First People of Australia, Perth, Australia. In this review, the authors focus on North American Indigenous groups, although others are discussed.
A revolutionary new device which could save the lives of stroke patients has been developed by a University of Wolverhampton expert.
Help for families with sick and disabled children in Wales is now available at the click of a mouse, Deputy Minister for Social Services Gwenda Thomas will announce.
Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (USDA HNRCA) studied mice fed high fat diets supplemented with curcumin and cell cultures incubated with curcumin.
The WHO on Wednesday announced plans for a clinical trial to test a new drug that "could halve the treatment period for river blindness [or onchocerciasis], a disease that threatens 100 million people mostly in Africa," AFP/Dow Jones Newswires/CNN Money reports (7/1). "This is a devastating illness that has plagued 30 African countries for centuries, in particular the populations in the most remote areas "beyond the end of the road,"" Uche Amazigo, director of the African Programme for Onchocerciasis Control (APOC), said (ANI/Thaindian.com, 7/1).
Michel Sidibe, the executive director of UNAIDS, voiced concerns that wealthy nations who previously pledged to help Africa stop the spread of HIV/AIDS during the G8 summit four years ago, might instead use funds to bolster their own ailing economies, Reuters reports. "Before this financial crisis, the world came together and this solidarity helped put more than 3.5 million people on treatment," Sidibe told reporters during the African Union summit in Sirte, Libya. "I am very concerned because ... the leaders of this world have the political obligation, or responsibility to really fix the market but they have also the moral obligation to not abandon those ... people on treatment and not to break the hope of the 14 million (AIDS) orphans," he said.
The Rockefeller Foundation launched a $100 million, five-year initiative aimed at improving health systems in Asia and Africa, Judith Rodin, the foundation"s president, said in a speech on Wednesday in Nairobi, Kenya, Xinhua reports. The Transforming Health Systems (THS) project will begin with investments in Ghana, Rwanda and Vietnam, and will also support certain regional and global activities (Ooko, 7/1). The goal of THS is to "help countries in Africa and Asia that lack the latest treatments and technology; and where many people are forced to pay their medical bills out of pocket," VOA News writes (DeCapua, 7/1).
President Barack Obama pitched his health reform proposal Wednesday at a town hall meeting in Annandale, Va., asking the public and Congress to deliver on health care reform.
While CNN reports that the American Medical Association"s new president, J. James Rohack, is open to a government-funded health insurance option, others report that the system the AMA now endorses is not a public plan, but the heavily managed private plan that federal employees participate in.